Risks in the use of anabolic steroids: Testosterone

What is testosterone?

Main male sex hormone which is synthesized mainly in the testis Leydig cells, and on the other hand, the peel adrenal and ovarian cancer.

The pituitary gonadotropin LH, luteinizing hormone, is the specific regulatory hormone testosterone production.

In fact, we could say that it is a pro-hormone as to perform its physiological or pharmacological action in some tissues effectors, this should be reduced to dihydrotestosterone (DHT) by the enzyme 5 alpha-reductase.

As already mentioned, the synthesis of this substance occurs mainly in the testis and is synthesized from cholesterol oxidative degradation, which depends on the luteizante hormone (adult), together with follicle stimulating hormone (the periods of development).

The androgens testosterone and readily cross cell membrane and bind to specific intracellular receptors. The steroid-receptor complex is activated and is transported to the nucleus and binds DNA at a receptor site, increasing the activity of RNA polymerase and formation of messenger RNAs stimulating the synthesis of cellular proteins responsible for the final action fisiofarmacol?gicas. Skeletal muscle does not have testosterone receptors or DHT by the anabolic effects are not yet sufficiently explained. It has been suggested that androgens in muscle could block the cytosolic glucocorticoid receptors by inhibiting the catabolic action of these agents.

Effects

Some of the effects caused by testosterone than those related to the sexual organs are:

1. Increased muscle mass (anabolic)

2. Increases lipolysis.

3. Improves protein synthesis. (For the generation of a positive nitrogen balance)

4. Stimulates eritropoyesis (formation of red blood cells).

5. Increase in the number of contractile proteins which implies an improvement of the contractile capacity of muscle.

6. Increase the levels of phosphocreatine: immediate energy

7. proliferation of the sebaceous glands. The appearance of acne can be related with this effect.
8. thickening of the skin.

9. Hypertrophy of the larynx and producing a permanent record voice.

10. Male hair Distribution: pubis, trunk, extremities and beard. Testosterone has a genetically determined relationship with the appearance of baldness in men.

11. Increase the growth rate of the broad bones at puberty, and increased stature.

12. Closing of the epiphyseal plates and combination of cartilage.

13. aggressive behavior and greater physical and muscle strength in men than in women.

14. The anabolic actions are also evident in other organ systems: liver, kidney, heart, bone marrow, etc.

Use today

Testosterone is an old acquaintance, in gyms mostly.

Thousands of users, most often without a medical check, decide to use this hormone or its derivatives for the anabolic properties of the taking for granted that will be multiple benefits they will get and minimum risk to suffer.

The acceleration of muscle growth, increased bone maturation, improved recoverability between sessions are some of the main reasons that lead to these users to use this type of supplementation without being aware of the many problems that the use of the same can be derived .

In gyms is openly admits only the use of vitamin compounds, natural medicinal substances and including testosterone precursors that supposedly stimulate the production of this hormone in the body (are now called "natural bodybuilders", using products like WPR10, WPP11, GP01 , RF TEST 05. that as has been said, the only thing they do is to increase the activity of our own testosterone without introducing more amount in our body).

After all, everyone knows that inadvertently also use hormonal anabolic unchecked, fomented by various specialty stores and even over the Internet through a few pages even offer pure testosterone in 48 hours.

When a bodybuilder or user enters in your body by hormonal anabolic first observed remarkable progress since it briefly the body is with a surplus of this substance. However, after a while of use, they cease to act the same way, mainly due to the remoteness of production of own endogenous hormones, which disappear once the regulation to decreases in androgen receptors.

From there to follow experiencing improvements will be forced to continually raise the exogenous administration of hormones, with the risk that this dynamic entails.

Also, you have to emphasize the fact that each hormone is interlinked with others and an increase or decrease in their levels always affects the overall balance. When a hormone increases its presence in the body naturally, this in turn activates certain mechanisms that regulate and balance the other factors involved. Otherwise, when the increase is exogenously this escapes their control and can not in any way to adjust and balance the other related parameters.

The testosterone used in gyms clandestinely almost never found in pure form, as is almost always mixed with other components. The purpose of these components called esters, is to prevent a sudden increase in the level of this hormone in the body, to allow testosterone esters is absorbed by time lapses and no sudden avoiding the aforementioned exogenous surplus.

We find in the market various forms of testosterone propionate testosterone, Enanthate, Sustanon ... .. Ranging in system speed range, holding that the faster one acts testosterone, larger effects experience. The goal is to find a testosterone not strike fast system because it is rapidly converted to estrogen, and does not act as a long-term serious that difficult to control.

Anabolic steroids are taken orally or inject and athletes seeking to take them into weeks or months cycles, but continuously and in so-called cyclical usage patterns. This involves taking multiple doses of steroids over a given period, rest a while, and start again.

The combination of different classes of steroids by users is a common practice that aims to maximize its effectiveness and at the same time minimizing its adverse effects. This process is known as stacking ( "stacking").

For a novice using testosterone may be consumed 500 mg per week.

A cycle example for testosterone enanthate would be:

Querying multiple magazines and web pages, we can see how there are multiple sites in that it promotes the use of said substance through careful studies that combine to perfection use dose, rest periods, inhibiting substances effects, more suitable types ... in Ultimately, we see how the use of anabolic steroids has become a business "illegal" that takes advantage of people without the proper knowledge and puts them on a path full of future problems for your health.

At present some statistics even say that 65% of elite athletes use them attached to products that hide the relevant evidence of doping.

Risks of its use and its derivatives

Like all hormones, testosterone in the body should be catabolized. It will be due to the process of cannibalization that the user body undergoes certain changes in its internal balance.

Two main forms of cannibalization has testosterone:

1. Aromatization: converts testosterone to estradiol and its metabolites (estrogen: female sex hormone).
2. Reduction: conversion to dihydrotestosterone DHT, already mentioned.
Usually, by increasing our testosterone levels well in pure form or derivatives, we are increasing our cannibalization rates and as a consequence, the increase of its products (estradiol and DHT).

The increased estrogen concentration involves:

- Awakening of female recipients in men who should not turn up. (Grows breasts, gynecomastia, irreversible in most cases).
- Increases water retention: edema formation. As a consequence, increases the intra and extracapillary volume (increased plasma volume) with the consequent increase in blood pressure that can trigger in a heart failure.

The increase in DHT involves:

- Change up the DHT receptors in the hair follicles and the prostate that will be used to: alopecia (the user is bald) and possible prostate cancers (for cellular apoptosis).

- The liver produces cholestasis (blockage of the bile ducts).

Other effects from the consumption of anabolic steroids are:

- In people who are not physically mature may cause premature closure of the epiphysis of the large bones, so the final height can be reduced.

- Suppress the secretion of gonadotropic hormones that control development and function of the gonads (testes and ovaries). In males, the gonadotropin reduction can produce testicular atrophy, reduction of testosterone secretion and fewer sperm

- In women gonadotropins are required for ovulation and the secretion of estrogen, so a reduction of these hormones disrupts these processes and menstruation

- Also in women can produce masculinization, regression of the breasts, enlargement of the clitoris, the voice to deepen and facial hair growth.

- Total Cholesterol tends to increase. While HDL cholesterol shows a marked reduction, well below the normal line LDL cholesterol shows a variable response: a rapid increase or no change.

- Affectation of the immune system, which derives in reducing the effectiveness of the defense system.

- The use of steroids decreases glucose tolerance, whereas there is an increase in insulin resistance. These changes mimic Type II diabetes.

- Personality changes, aggressive behavior and euphoria

- Other side effects of AE are euphoria, confusion, sleep disorders, pathological anxiety, paranoia and hallucinations.

Conclusion

Leaving to one side the elite sport in which athletes are greatly pressed against the achievement of victory (yet without being justified), I consider that the true insistence we must do is the usual user "street" without any control ( or the unfit control) decides if the use of these substances in order to improve their physical appearance in a quick way and going over any healthy recommendation.

As already has been said there are multiple economic interests that some of the companies dedicated to this world have in this market, which sometimes leads them to cross the line of social ethics urging people to use products in quantities nothing commendable and without any medical supervision.
So basically I think that at least, if the user decides to "get into something" to do considering what to have since most of the time tell you the miraculous benefits, but never the countless future problems.

Hence, simply say that what quickly can, quickly will that leave us interested in the substance "miracle" and to trust more in the appropriate professional sport and health (fisios, doctors ...) that through their advice and our firm succeed in our desired results although perhaps come later will be more rewarding.